University of Missouri National Swine Research and Resource Center

University of Missouri National Swine Research and Resource Center

The National Swine Research and Resource Center is a state-of-the-art laboratory and production facility to create genetically engineered transgenic and knockout swine for human disease research. It establishes a worldwide repository for cryogenically preserved, valuable genetic swine models and is intended to have a substantial impact on human research into those diseases that can be recreated in swine models.  The research subjects produced have had immediate impact on disease research at a world-wide scale as well as fundamental research into transgenic and knockout procedures.

This new 19,550 sf facility is segregated into two primary areas – laboratory/support and animal holding.  The laboratory spaces include a transgenic laboratory, a cryo-biology laboratory and several support spaces.  While BSL3 laboratory facilities are designed to prevent contaminants from leaving the building, this facility requires a pathogen free interior environment and must prevent contaminants from entering the facility.  All personnel need to shower-in to maintain a pathogen free environment. A wipe down air lock is provided where small packages and mail are manually disinfected and placed in a pass through air lock for collection from the interior.  A pass through fumigation chamber allows large deliveries of bulk feed and bedding to be sterilized using a vaporized hydrogen peroxide generator.  An animal “out” area is segregated by walls from the receiving dock for transfer of transgenic swine out of the facility. 

Animal waste is handled inside the facility by a series of shallow pits designed to limit odor propagation throughout the facility.  A new stand-alone pretreatment facility located on site captures a majority of the solid waste material prior to the connection to the City sanitary sewer system. The National Swine Research and Resource Center was completed in 2006 for a construction cost of $304.80 per square foot.